Cellular consequences of inositol depletion.

نویسندگان

  • Rania M Deranieh
  • Miriam L Greenberg
چکیده

The inositol-depletion hypothesis was suggested to explain the therapeutic mechanism of mood-stabilizing drugs. Focus was previously on the phosphatidylinositol signalling pathway and on the regulatory roles of Ins(3,4,5)P(3) and DAG (diacylglycerol). Recent findings indicate that inositol and inositol-containing molecules, including phosphoinositides and inositol phosphates, have signalling and regulatory roles in many cellular processes. This suggests that depleting inositol may lead to perturbation of a wide range of cellular functions, at least some of which may be associated with bipolar disorder.

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عنوان ژورنال:
  • Biochemical Society transactions

دوره 37 Pt 5  شماره 

صفحات  -

تاریخ انتشار 2009